Believe it or not, I actually have a few comments on this one that I remember from when I first saw it.
The shirt she is wearing really morphs to her body, and that's cool, but the bulge under her breast on her right side looks a bit awkward. Although I assume its just her shirt pulling away from her body, it looks like her muscle and a bit strange. Also, the kinda blur/glow effect on the drawing really makes her look neat, almost mystical, but it makes the background look a bit out of place. The clouds and blocks look bland with the glow.
But that's me being a total prick as far as criticism. Take it with a grain of salt considering I love this piece.
Wow. She's really cute. ^_^ I like this type of character more than Anthro characters (not that anthro's bad or anything), and you did a very good job on the design. The pose, lighting, outfit, and basically everything else is great!
Jessica she is incredible! The colour of her fur makes her look more like a were-fox to me but then her tail would be that brownish-red too. To be honest, it doesn't matter what she looks like she should be, she is what you make her. She is adorable in that lovely furry jumper and warm happy expression. Those golden eyes are stunning and her hair and ears are so cute. The green hot-pants and thigh strap are very sexy, as is her pose; that is one sexy ass!
I have to agree with Crybringer that the background could really do with more detail and a piece this good deserves a good background. Still, the moon and clouds are pretty and they do create an atmosphere that suits the character, it's mainly just those weird blocks that don't look quite right. But background aside, she is a very very good character, I like her alot. Beyond making her part of this new look on monsters series, I reckon you ought to expand her as a permanent character.